Mouse Anti-ST6GAL1 Recombinant Antibody (7H204) (CBMAB-C4292-CN)

Name: Mouse Anti-ST6GAL1 Recombinant Antibody (7H204)
SKU: CBMAB-C4292-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

7H204

Application

FC, IHC

Immunogen

PMA stimulated PBL

Specificity

Human

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 5% glycerol, 0.2% BSA

Preservative

0.05% Sodium azide

Purity

> 90%

More Infomation

Target

Full Name

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

Introduction

This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

6480

UniProt ID

P15907

Alternative Names

ST6N; SIAT1; ST6GalI

Function

Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

Biological Process

Biological Process humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process N-acetylneuraminate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of chemotaxisIEA:Ensembl
Biological Process negative regulation of macrophage apoptotic processIEA:Ensembl
Biological Process O-glycan processingTAS:Reactome
Biological Process positive regulation of mononuclear cell proliferationIEA:Ensembl
Biological Process protein N-linked glycosylation via asparagineManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sialylationIEA:Ensembl
Biological Process regulation of substrate adhesion-dependent cell spreadingIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process sialylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process viral protein processingTAS:Reactome

Cellular Location

Golgi apparatus, Golgi stack membrane
Secreted
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Topology

Cytoplasmic: 1-9
Helical: 10-26
Lumenal: 27-406

PTM

The soluble form derives from the membrane form by proteolytic processing.
The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.
N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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