ST6GAL1
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants.
Full Name
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Function
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
Biological Process
Biological Process humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process N-acetylneuraminate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of chemotaxisIEA:Ensembl
Biological Process negative regulation of macrophage apoptotic processIEA:Ensembl
Biological Process O-glycan processingTAS:Reactome
Biological Process positive regulation of mononuclear cell proliferationIEA:Ensembl
Biological Process protein N-linked glycosylation via asparagineManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sialylationIEA:Ensembl
Biological Process regulation of substrate adhesion-dependent cell spreadingIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process sialylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process viral protein processingTAS:Reactome
Biological Process N-acetylneuraminate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of chemotaxisIEA:Ensembl
Biological Process negative regulation of macrophage apoptotic processIEA:Ensembl
Biological Process O-glycan processingTAS:Reactome
Biological Process positive regulation of mononuclear cell proliferationIEA:Ensembl
Biological Process protein N-linked glycosylation via asparagineManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sialylationIEA:Ensembl
Biological Process regulation of substrate adhesion-dependent cell spreadingIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process sialylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process viral protein processingTAS:Reactome
Cellular Location
Golgi apparatus, Golgi stack membrane
Secreted
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Secreted
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Topology
Cytoplasmic: 1-9
Helical: 10-26
Lumenal: 27-406
Helical: 10-26
Lumenal: 27-406
PTM
The soluble form derives from the membrane form by proteolytic processing.
The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.
N-glycosylated.
The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.
N-glycosylated.
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Anti-ST6GAL1 antibodies
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CompareTarget: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 0.N.161
Application*: P, C, F, IC/IF
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 7H204
Application*: FC, IH
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: B-L5
Application*: E
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-4465
Application*: F, IC, C, P, WB
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-4464
Application*: F, IF, IH
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2890
Application*: E, IP, WB
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1814
Application*: WB
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1139
Application*: E
Target: ST6GAL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4710
Application*: P
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: ZB55
Application*: F, IH, IF, MC
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXC-1848
Application*: F
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXC-0698
Application*: F, IF, IH
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: LN1
Application*: F, C, P
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-3141
Application*: WB
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LN-1
Application*: C, P
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E12
Application*: E, IP, WB
Target: ST6GAL1
Sensitivity: 0.48 ng/mL
Detection Range: 1-400 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: St6gal1
Sensitivity: 0.027 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: ST6GAL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 27-403
Tag: His Tag
Target: ST6GAL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 27-403
Tag: His Tag
Target: ST6GAL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 27-406
Tag: His Tag
Target: ST6GAL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 27-406
Tag: His Tag
Target: ST6GAL1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 27-406
Tag: His Tag
Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYY-C0641
Application*: F, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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