ST6GAL1

This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants.
Full Name
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Function
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
Biological Process
Biological Process humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process N-acetylneuraminate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of chemotaxisIEA:Ensembl
Biological Process negative regulation of macrophage apoptotic processIEA:Ensembl
Biological Process O-glycan processingTAS:Reactome
Biological Process positive regulation of mononuclear cell proliferationIEA:Ensembl
Biological Process protein N-linked glycosylation via asparagineManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sialylationIEA:Ensembl
Biological Process regulation of substrate adhesion-dependent cell spreadingIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process sialylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process viral protein processingTAS:Reactome
Cellular Location
Golgi apparatus, Golgi stack membrane
Secreted
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Topology
Cytoplasmic: 1-9
Helical: 10-26
Lumenal: 27-406
PTM
The soluble form derives from the membrane form by proteolytic processing.
The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.
N-glycosylated.
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Anti-ST6GAL1 antibodies

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Mouse Anti-ST6GAL1 Recombinant Antibody (0.N.161) (CBMAB-C1394-LY)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 0.N.161
Application*: P, C, F, IC/IF
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (7H204) (CBMAB-C4292-CN)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 7H204
Application*: FC, IH
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (B-L5) (CBMAB-C5857WJ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: B-L5
Application*: E
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (CBWJC-4465) (CBMAB-C5856WJ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-4465
Application*: F, IC, C, P, WB
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (CBWJC-4464) (CBMAB-C5855WJ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-4464
Application*: F, IF, IH
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (CBXS-2890) (CBMAB-S5639-CQ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2890
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (CBXS-1814) (CBMAB-S4623-CQ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1814
Application*: WB
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (CBXS-1139) (CBMAB-S4023-CQ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1139
Application*: E
Datasheet SDS

Rabbit Anti-ST6GAL1 Recombinant Antibody (CBXS-4710) (CBMAB-S1941-CQ)

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Target: ST6GAL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4710
Application*: P
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (ZB55) (CBMAB-S0202-CQ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: ZB55
Application*: F, IH, IF, MC
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (CBXC-1848) (CBMAB-C3368-CQ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXC-1848
Application*: F
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (CBXC-0698) (CBMAB-C3367-CQ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXC-0698
Application*: F, IF, IH
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (LN1) (CBMAB-C2531-CQ)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: LN1
Application*: F, C, P
Datasheet SDS

Mouse Anti-ST6GAL1 (AA 27-406) Recombinant Antibody (CBFYC-3141) (CBMAB-C3218-FY)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-3141
Application*: WB
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (LN-1) (CBMAB-C9364-LY)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LN-1
Application*: C, P
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (2E12) (CBMAB-C4970-LY)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E12
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-ST6GAL1 Recombinant Antibody (CBYY-C0641) (CBMAB-C1931-YY)

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Target: ST6GAL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYY-C0641
Application*: F, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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