Mouse Anti-ST8SIA1 Recombinant Antibody (CBLG1-2446) (CBMAB-G6613-LY)

Name: Mouse Anti-ST8SIA1 Recombinant Antibody (CBLG1-2446)
SKU: CBMAB-G6613-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBLG1-2446

Application

Immunogen

FM9 melanoma cells

Specificity

Human

Antibody Isotype

IgG3

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 1

Introduction

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene.

Entrez Gene ID

6489

UniProt ID

Q92185

Alternative Names

GD3S; SIAT8; SIAT8-A; SIAT8A; ST8SiaI

Function

Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid (PubMed:7937974, PubMed:8058740, PubMed:8195250, PubMed:8631981, PubMed:8706663, PubMed:18348864, PubMed:22885356).
Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3 (PubMed:8631981).
Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed:8706663).
Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells (PubMed:22885356).

Biological Process

Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to heatIEA:Ensembl
Biological Process epithelial cell proliferationIEA:Ensembl
Biological Process glycosphingolipid biosynthetic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process N-glycan processingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process oligosaccharide metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of epithelial cell proliferationIEA:Ensembl
Biological Process protein glycosylationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-29
Helical: 30-48
Lumenal: 49-356

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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