ST8SIA1

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene.
Full Name
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 1
Function
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid (PubMed:7937974, PubMed:8058740, PubMed:8195250, PubMed:8631981, PubMed:8706663, PubMed:18348864, PubMed:22885356).
Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3 (PubMed:8631981).
Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed:8706663).
Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells (PubMed:22885356).
Biological Process
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to heatIEA:Ensembl
Biological Process epithelial cell proliferationIEA:Ensembl
Biological Process glycosphingolipid biosynthetic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process N-glycan processingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process oligosaccharide metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of epithelial cell proliferationIEA:Ensembl
Biological Process protein glycosylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-29
Helical: 30-48
Lumenal: 49-356
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Anti-ST8SIA1 antibodies

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Mouse Anti-ST8SIA1 Recombinant Antibody (CBXS-5531) (CBMAB-S2738-CQ)

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Target: ST8SIA1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXS-5531
Application*: C
Datasheet SDS

Mouse Anti-ST8SIA1 Recombinant Antibody (CBXS-5067) (CBMAB-S2288-CQ)

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Target: ST8SIA1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXS-5067
Application*: WB, E
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Mouse Anti-ST8SIA1 Recombinant Antibody (CBLG1-2446) (CBMAB-G6613-LY)

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Target: ST8SIA1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBLG1-2446
Application*: F
Datasheet SDS

Mouse Anti-ST8SIA1 Recombinant Antibody (CBLG1-2444) (CBMAB-G6611-LY)

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Target: ST8SIA1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBLG1-2444
Application*: F
Datasheet SDS

Mouse Anti-ST8SIA1 Recombinant Antibody (R24) (CBMAB-G6610-LY)

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Target: ST8SIA1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: R24
Application*: P, C, F
Datasheet SDS

Mouse Anti-ST8SIA1 Recombinant Antibody (MB3.6) (CBMAB-G6609-LY)

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Target: ST8SIA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: MB3.6
Application*: IF, F
Datasheet SDS

Mouse Anti-ST8SIA1 Recombinant Antibody (CBLG1-320) (CBMAB-G1191-LY)

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Target: ST8SIA1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBLG1-320
Application*: F
Datasheet SDS

Human Recombinant ST8SIA1 protein, His Tag (V2LY-0526-LY6961)

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Target: ST8SIA1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 49-356
Tag: His Tag
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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