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Mouse Anti-SUB1 Recombinant Antibody (CBXS-1129) (CBMAB-S4013-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1129
Antibody Isotype
IgG1
Application
WB, IF, IF, IP

Basic Information

Immunogen
Recombinant Human SUB1/PC4 protein
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SUB1 homolog (S. cerevisiae)
Entrez Gene ID
10923
UniProt ID
P53999
Alternative Names
P15; PC4; p14
Function
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
Biological Process
Biological Process negative regulation of DNA metabolic processManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of transcription initiation by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA polymerase II promoter clearanceManual Assertion Based On ExperimentIDA:WormBase
Biological Process SMAD protein signal transductionIEA:Ensembl
Cellular Location
Nucleus
PTM
Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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