SUB1

SUB1 (SUB1 Homolog, Transcriptional Regulator) is a protein coding gene. Diseases associated with SUB1 include Tinea Unguium. Gene Ontology annotations related to this gene include single-stranded DNA binding.

SUB1 homolog (S. cerevisiae)

General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).

Biological Process negative regulation of DNA metabolic processManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of transcription initiation by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA polymerase II promoter clearanceManual Assertion Based On ExperimentIDA:WormBase
Biological Process SMAD protein signal transductionIEA:Ensembl

Nucleus

Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.