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Mouse Anti-SUB1 Recombinant Antibody (H-12) (CBMAB-P3700-YC)

Provided herein is a Mouse monoclonal antibody against Human SUB1 homolog, transcriptional regulator. The antibody can be used for immunoassay techniques, such as WB, IP, IF, IHC-P, ELISA.
See all SUB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
H-12
Antibody Isotype
IgG
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SUB1 homolog (S. cerevisiae)
Introduction
SUB1 (SUB1 Homolog, Transcriptional Regulator) is a protein coding gene. Diseases associated with SUB1 include Tinea Unguium. Gene Ontology annotations related to this gene include single-stranded DNA binding.
Entrez Gene ID
10923
UniProt ID
P53999
Alternative Names
P15; PC4; p14
Function
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
Biological Process
Biological Process negative regulation of DNA metabolic processManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of transcription initiation by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA polymerase II promoter clearanceManual Assertion Based On ExperimentIDA:WormBase
Biological Process SMAD protein signal transductionIEA:Ensembl
Cellular Location
Nucleus
PTM
Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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