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Mouse Anti-SUGT1 Recombinant Antibody (1A10) (CBMAB-A8763-LY)

The product is antibody recognizes SUGT1. The antibody 1A10 immunoassay techniques such as: WB, ELISA.
See all SUGT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A10
Antibody Isotype
IgG3, κ
Application
WB, ELISA

Basic Information

Immunogen
SUGT1 (NP_006695, 151 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SUGT1
Introduction
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
10910
UniProt ID
Q9Y2Z0
Alternative Names
SGT1
Function
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Biological Process
Biological Process mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein stabilizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein stabilityManual Assertion Based On ExperimentIDA:AgBase
Cellular Location
Cytoplasm
Nucleus
Translocates to the nucleus upon heat shock, requiring S100A6.
PTM
Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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