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SUGT1

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

SUGT1

Function

May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Biological Process

Biological Process mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein stabilizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein stabilityManual Assertion Based On ExperimentIDA:AgBase

Cellular Location

Cytoplasm
Nucleus
Translocates to the nucleus upon heat shock, requiring S100A6.

PTM

Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.

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Anti-SUGT1 antibodies

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Mouse Anti-SUGT1 Recombinant Antibody (6G5) (CBMAB-A8764-LY)

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Target: SUGT1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human, Mouse, Rat

Clone: 6G5

Application*: WB, E

Mouse Anti-SUGT1 Recombinant Antibody (1A10) (CBMAB-A8763-LY)

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Target: SUGT1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 1A10

Application*: WB, E

Mouse Anti-SUGT1 Recombinant Antibody (CBXS-3381) (CBMAB-S6116-CQ)

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Target: SUGT1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: CBXS-3381

Application*: E, IF, WB

Mouse Anti-SUGT1 Recombinant Antibody (CBXS-2059) (CBMAB-S4826-CQ)

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Target: SUGT1

Host: Mouse

Specificity: Human

Clone: CBXS-2059

Application*: WB, IP, IF, E

Mouse Anti-SUGT1 Recombinant Antibody (CBXS-2045) (CBMAB-S4812-CQ)

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Target: SUGT1

Host: Mouse

Specificity: Human

Clone: CBXS-2045

Application*: WB, IP, IF, E

Mouse Anti-SUGT1 Recombinant Antibody (CBXS-0840) (CBMAB-S3764-CQ)

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Target: SUGT1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: CBXS-0840

Application*: SE, E, WB, IF

Mouse Anti-SUGT1 Recombinant Antibody (CBXS-3792) (CBMAB-S1063-CQ)

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Target: SUGT1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human, Mouse, Rat

Clone: CBXS-3792

Application*: E, IP, WB

SUGT1 Matched Antibody Pair (1168) (APMAB-1168LY)

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Target: SUGT1

Specificity: Human

SUGT1 Matched Antibody Pair (1167) (APMAB-1167LY)

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Target: SUGT1

Specificity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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