SUGT1
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
SUGT1
Function
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Biological Process
Biological Process mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein stabilizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein stabilityManual Assertion Based On ExperimentIDA:AgBase
Biological Process protein stabilizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein stabilityManual Assertion Based On ExperimentIDA:AgBase
Cellular Location
Cytoplasm
Nucleus
Translocates to the nucleus upon heat shock, requiring S100A6.
Nucleus
Translocates to the nucleus upon heat shock, requiring S100A6.
PTM
Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
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Anti-SUGT1 antibodies
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CompareTarget: SUGT1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: 6G5
Application*: WB, E
Target: SUGT1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1A10
Application*: WB, E
Target: SUGT1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXS-3381
Application*: E, IF, WB
Target: SUGT1
Host: Mouse
Specificity: Human
Clone: CBXS-2059
Application*: WB, IP, IF, E
Target: SUGT1
Host: Mouse
Specificity: Human
Clone: CBXS-2045
Application*: WB, IP, IF, E
Target: SUGT1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXS-0840
Application*: SE, E, WB, IF
Target: SUGT1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-3792
Application*: E, IP, WB
Target: SUGT1
Specificity: Human
Target: SUGT1
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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