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Mouse Anti-SYP Recombinant Antibody (CBT1179) (V2LY-0625-LY2967)


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Tested Data
Mouse Anti-SYP Recombinant Antibody (CBT1179) (V2LY-0625-LY2967) in IHC
Mouse Anti-SYP Recombinant Antibody (CBT1179) (V2LY-0625-LY2967) in IHC
Mouse Anti-SYP Recombinant Antibody (CBT1179) (V2LY-0625-LY2967) in WB
Mouse Anti-SYP Recombinant Antibody (CBT1179) (V2LY-0625-LY2967) in WB

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBT1179
Antibody Isotype
IgG
Application
WB, IHC-P, IF, ELISA

Basic Information

Immunogen
Purified recombinant fragment of SYP expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
IHC1:200-1:1,000
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
BSA, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
synaptophysin
Entrez Gene ID
6855
Function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Biological Process
Biological Process cellular response to organic substanceIEA:Ensembl
Biological Process endocytosisISS:UniProtKB
Biological Process regulation of long-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of neuronal synaptic plasticityIBA:GO_Central1 Publication
Biological Process regulation of opioid receptor signaling pathwayISS:UniProtKB
Biological Process regulation of short-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process synaptic vesicle endocytosisIEA:Ensembl
Biological Process synaptic vesicle maturationNAS:UniProtKB1 Publication
Biological Process synaptic vesicle membrane organizationNAS:UniProtKB1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome
Involvement in disease
Intellectual developmental disorder, X-linked 96 (XLID96):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Topology
Cytoplasmic: 1-25
Helical: 26-49
Vesicular: 50-106
Helical: 107-130
Cytoplasmic: 131-137
Helical: 138-161
Vesicular: 162-199
Helical: 200-223
Cytoplasmic: 224-313
PTM
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Phosphorylated by SRC.
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For research use only. Not intended for any clinical use.

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