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SYP

SYP is an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability.

Full Name

synaptophysin

Function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).

Biological Process

Biological Process cellular response to organic substanceIEA:Ensembl
Biological Process endocytosisISS:UniProtKB
Biological Process regulation of long-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of neuronal synaptic plasticityIBA:GO_Central1 Publication
Biological Process regulation of opioid receptor signaling pathwayISS:UniProtKB
Biological Process regulation of short-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process synaptic vesicle endocytosisIEA:Ensembl
Biological Process synaptic vesicle maturationNAS:UniProtKB1 Publication
Biological Process synaptic vesicle membrane organizationNAS:UniProtKB1 Publication

Cellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome

Involvement in disease

Intellectual developmental disorder, X-linked 96 (XLID96):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Topology

Cytoplasmic: 1-25
Helical: 26-49
Vesicular: 50-106
Helical: 107-130
Cytoplasmic: 131-137
Helical: 138-161
Vesicular: 162-199
Helical: 200-223
Cytoplasmic: 224-313

PTM

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Phosphorylated by SRC.

Anti-SYP antibodies

Rabbit Anti-SYP Recombinant Antibody (D40C4) (CBMAB-CP2673-LY)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D40C4

Application*: WB, IP

Mouse Anti-SYP Recombinant Antibody (3B3) (CBMAB-A8814-LY)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3B3

Application*: WB, E

Rabbit Anti-SYP Monoclonal Antibody (SP11) (CBMAB-1590-YC)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: SP11

Application*: P, WB

Rabbit Anti-SYP Monoclonal Antibody (EP1098Y) (CBMAB-1589-YC)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EP1098Y

Application*: F, IC, IF, P, IP, WB

Mouse Anti-SYP Monoclonal Antibody (7H12) (CBMAB-1588-YC)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: 7H12

Application*: IH, WB

Mouse Anti-SYP Monoclonal Antibody (EP10) (CBMAB-1587-YC)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Hamster

Clone: EP10

Application*: IF, IC, P, IP, WB

Rabbit Anti-SYP Monoclonal Antibody (8H2L12) (CBMAB-1586-YC)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 8H2L12

Application*: IF, IC, F, WB

Rabbit Anti-SYP Monoclonal Antibody (YE269) (CBMAB-1585-YC)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Donkey

Clone: YE269

Application*: IC, IF, C, P, WB

Mouse Anti-SYP Monoclonal Antibody (SY38) (CBMAB-1584-YC)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Hamster, Cattle

Clone: SY38

Application*: F, IC, IF, C, P, WB

Rabbit Anti-SYP Monoclonal Antibody (EPR1097-2) (CBMAB-1583-YC)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EPR1097-2

Application*: IC, IF, WB

Mouse Anti-SYP Recombinant Antibody (CF419) (CBMAB-FT098LY)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CF419

Application*: ELISA, WB, IF

Mouse Anti-SYP Recombinant Antibody (7H12) (CBMAB-AO1001LY)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: 7H12

Application*: WB

Mouse Anti-SYP Recombinant Antibody (3G12) (CBMAB-BR463LY)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG2B

Specificity: Human, Mouse, Rat

Clone: 3G12

Application*: FC, IF, ICC, WB

Mouse Anti-SYP Recombinant Antibody (IHC669) (CBMAB-MA237-YC)

SDS

Target: SYP

Host: Mouse

Specificity: Human

Clone: IHC669

Application*: IH

Mouse Anti-SYP Recombinant Antibody (CBXS-5847) (CBMAB-S0702-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Mouse, Zebrafish

Clone: CBXS-5847

Application*: IC, IP, E, WB, IH

Rabbit Anti-SYP Recombinant Antibody (CBXS-5938) (CBMAB-S0787-CQ)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXS-5938

Application*: F, IC, IF, WB

Mouse Anti-SYP Recombinant Antibody (CBXS-3854) (CBMAB-S1124-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3854

Application*: WB, IH

Mouse Anti-SYP Recombinant Antibody (CBXS-3946) (CBMAB-S1209-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-3946

Application*: IF, P, WB

Mouse Anti-SYP Recombinant Antibody (CBXS-4305) (CBMAB-S1550-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: CBXS-4305

Application*: WB, P

Mouse Anti-SYP Recombinant Antibody (CBXS-4317) (CBMAB-S1562-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgM

Specificity: Mouse

Clone: CBXS-4317

Application*: WB

Mouse Anti-SYP Recombinant Antibody (CBXS-4764) (CBMAB-S1992-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-4764

Application*: IF, WB

Mouse Anti-SYP Recombinant Antibody (Syn-58) (CBMAB-S6651-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: Syn-58

Application*: E, IH, WB

Mouse Anti-SYP Recombinant Antibody (CBXS-1992) (CBMAB-S4760-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-1992

Application*: IH, IC

Mouse Anti-SYP Recombinant Antibody (CBXS-2340) (CBMAB-S5099-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-2340

Application*: F, IH, WB

Mouse Anti-SYP Recombinant Antibody (CBXS-2367) (CBMAB-S5125-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBXS-2367

Application*: IF, IH, WB

Mouse Anti-SYP Recombinant Antibody (CBXS-2481) (CBMAB-S5238-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBXS-2481

Application*: E, IH, WB

Mouse Anti-SYP Recombinant Antibody (CBXS-2972) (CBMAB-S5719-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgM

Specificity: Cat, Hamster, Human, Pig, Rat

Clone: CBXS-2972

Application*: E, IH, WB

Mouse Anti-SYP Recombinant Antibody (CBXS-3132) (CBMAB-S5874-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgM

Specificity: Hamster, Human, Rat

Clone: CBXS-3132

Application*: E, IH, WB

Mouse Anti-SYP Recombinant Antibody (CBXS-3300) (CBMAB-S6039-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human, Mouse, Rat

Clone: CBXS-3300

Application*: IF, IH, WB

Mouse Anti-SYP (C-Term) Recombinant Antibody (CBXS-3430) (CBMAB-S6161-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBXS-3430

Application*: IH, WB

Rabbit Anti-SYP (C-Term) Recombinant Antibody (CBXS-3525) (CBMAB-S6254-CQ)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXS-3525

Application*: IC, IH, WB

Mouse Anti-SYP Recombinant Antibody (MRQ-40) (CBMAB-S6438-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: MRQ-40

Application*: P

Rabbit Anti-SYP (C-Term) Recombinant Antibody (Q21-Q) (CBMAB-S6491-CQ)

SDS

Target: SYP

Host: Rabbit

Specificity: Human

Clone: Q21-Q

Application*: IH

Rabbit Anti-SYP Recombinant Antibody (CBXS-6184) (CBMAB-S6500-CQ)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-6184

Application*: WB, IH

Mouse Anti-SYP Recombinant Antibody (SP15) (CBMAB-S6586-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: SP15

Application*: E, F, IF, WB

Rabbit Anti-SYP Recombinant Antibody (RM258) (CBMAB-BR462LY)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: RM258

Application*: IHC, WB

Mouse Anti-SYP Recombinant Antibody (SP17) (CBMAB-S6592-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgM

Specificity: Rat, Human, Pig

Clone: SP17

Application*: WB, E, IC

Mouse Anti-SYP Recombinant Antibody (SVP38) (CBMAB-S6645-CQ)

SDS

Target: SYP

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: SVP38

Application*: WB, IP

Mouse Anti-SYP Recombinant Antibody (CBXS-5686) (CBMAB-S0556-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Mouse, Rat, Cattle

Clone: CBXS-5686

Application*: IH, IP, WB

Mouse Anti-SYP Recombinant Antibody (SYP02) (CBMAB-S6653-CQ)

SDS

Target: SYP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: SYP02

Application*: P, WB

Mouse Anti-SYP Recombinant Antibody (CBXS-5703) (CBMAB-S0571-CQ)

SDS

Target: SYP

Host: Mouse

Specificity: Mouse, Rat, Human, Cattle

Clone: CBXS-5703

Application*: WB, IP

Rabbit Anti-SYP Recombinant Antibody (CBXS-5377) (CBMAB-S2590-CQ)

SDS

Target: SYP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXS-5377

Application*: WB, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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