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Mouse Anti-TACC2 Recombinant Antibody (CBYJT-1772) (CBMAB-T0833-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1772
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 727-1026 of human TACC2 (NP_008928) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 727-1026

Target

Full Name
Transforming Acidic Coiled-Coil Containing Protein 2
Introduction
TACC2 plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. It is Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). It may function in organizing centrosomal microtubules. It may act as a tumor suppressor protein. It may represent a tumor progression marker.
Entrez Gene ID
10579
UniProt ID
O95359
Alternative Names
AZU-1; ECTACC
Function
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity).
May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.
Biological Process
Biological Process cell population proliferationIBA:GO_Central1 Publication
Biological Process cerebral cortex developmentIBA:GO_Central1 Publication
Biological Process microtubule cytoskeleton organizationIBA:GO_Central1 Publication
Biological Process mitotic spindle organizationIEA:InterPro
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
PTM
Phosphorylated by TTK; which is required for localization in centrosome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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