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Mouse Anti-TADA2A Recombinant Antibody (CBYJT-1808) (CBMAB-T0870-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1808
Antibody Isotype
IgG1, κ
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TADA2A
Introduction
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. TADA2A is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex.
Entrez Gene ID
6871
UniProt ID
O75478
Alternative Names
Transcriptional Adaptor 2A; ADA2-Like Protein; TADA2L; Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Like; Transcriptional Adapter 2-Alpha; Transcriptional Adaptor 2 Alpha
Function
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity).
Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376).
May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).
Biological Process
Biological Process chromatin remodelingIBA:GO_Central1 Publication
Biological Process histone acetylationIC:ComplexPortal1 Publication
Biological Process histone H3 acetylationIDA:UniProtKB1 Publication
Biological Process histone H3-K14 acetylationIDA:ComplexPortal1 Publication
Biological Process positive regulation of histone acetylationIBA:GO_Central1 Publication
Biological Process regulation of cell cycleIMP:ComplexPortal1 Publication
Biological Process regulation of cell divisionIDA:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcriptionIMP:ComplexPortal1 Publication
Biological Process regulation of embryonic developmentIC:ComplexPortal
Biological Process regulation of histone deacetylationIMP:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process regulation of tubulin deacetylationIMP:ComplexPortal1 Publication
Cellular Location
Nucleus
Chromosome
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For research use only. Not intended for any clinical use.

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