Mouse Anti-TADA2A Recombinant Antibody (CBYJT-1809) (CBMAB-T0871-YJ)

Name: Mouse Anti-TADA2A Recombinant Antibody (CBYJT-1809)
SKU: CBMAB-T0871-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-1809

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TADA2A

Introduction

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. TADA2A is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex.

Entrez Gene ID

6871

UniProt ID

O75478

Alternative Names

Transcriptional Adaptor 2A; ADA2-Like Protein; TADA2L; Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Like; Transcriptional Adapter 2-Alpha; Transcriptional Adaptor 2 Alpha

Function

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity).
Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376).
May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).

Biological Process

Biological Process chromatin remodelingIBA:GO_Central1 Publication
Biological Process histone acetylationIC:ComplexPortal1 Publication
Biological Process histone H3 acetylationIDA:UniProtKB1 Publication
Biological Process histone H3-K14 acetylationIDA:ComplexPortal1 Publication
Biological Process positive regulation of histone acetylationIBA:GO_Central1 Publication
Biological Process regulation of cell cycleIMP:ComplexPortal1 Publication
Biological Process regulation of cell divisionIDA:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcriptionIMP:ComplexPortal1 Publication
Biological Process regulation of embryonic developmentIC:ComplexPortal
Biological Process regulation of histone deacetylationIMP:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process regulation of tubulin deacetylationIMP:ComplexPortal1 Publication

Cellular Location

Nucleus
Chromosome

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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