TADA2A

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. TADA2A is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex.

Full Name

TADA2A

Function

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity).
Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376).
May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).

Biological Process

Biological Process chromatin remodelingIBA:GO_Central1 Publication
Biological Process histone acetylationIC:ComplexPortal1 Publication
Biological Process histone H3 acetylationIDA:UniProtKB1 Publication
Biological Process histone H3-K14 acetylationIDA:ComplexPortal1 Publication
Biological Process positive regulation of histone acetylationIBA:GO_Central1 Publication
Biological Process regulation of cell cycleIMP:ComplexPortal1 Publication
Biological Process regulation of cell divisionIDA:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcriptionIMP:ComplexPortal1 Publication
Biological Process regulation of embryonic developmentIC:ComplexPortal
Biological Process regulation of histone deacetylationIMP:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process regulation of tubulin deacetylationIMP:ComplexPortal1 Publication

Cellular Location

Nucleus
Chromosome