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Mouse Anti-TAF1B Recombinant Antibody (CBYJT-1852) (CBMAB-T0919-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAF1B (TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B). The antibody can be used for immunoassay techniques, such as WB.
See all TAF1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1852
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-208 of human TAF1B (NP_005671) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-208

Target

Full Name
TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B
Introduction
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. TAF1B is one of the SL1-specific TAFs.
Entrez Gene ID
9014
UniProt ID
Q53T94
Alternative Names
TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kDa; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kD; RNA Polymerase I-Specific TBP-Associated Factor 63 KDa; Transcription Initiation Factor SL1/TIF-IB Subunit B; TATA Box-Binding Protein-Associated Factor 1B; TBP-Associated Factor 1B; TAFI63
Function
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
Biological Process
Biological Process DNA-templated transcriptionNAS:UniProtKB1 Publication
Biological Process nucleolar large rRNA transcription by RNA polymerase IIBA:GO_Central1 Publication
Biological Process RNA polymerase I preinitiation complex assemblyIDA:UniProtKB1 Publication
Cellular Location
Nucleus, nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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