Mouse Anti-TAF1B Recombinant Antibody (CBYJT-1856) (CBMAB-T0924-YJ)

Name: Mouse Anti-TAF1B Recombinant Antibody (CBYJT-1856)
SKU: CBMAB-T0924-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-1856

Application

Immunogen

Synthetic peptide corresponding to the middle region of human TAF1B

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

Middle region

More Infomation

Target

Full Name

TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B

Introduction

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. TAF1B is one of the SL1-specific TAFs.

Entrez Gene ID

9014

UniProt ID

Q53T94

Alternative Names

TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kDa; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kD; RNA Polymerase I-Specific TBP-Associated Factor 63 KDa; Transcription Initiation Factor SL1/TIF-IB Subunit B; TATA Box-Binding Protein-Associated Factor 1B; TBP-Associated Factor 1B; TAFI63

Function

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.

Biological Process

Biological Process DNA-templated transcriptionNAS:UniProtKB1 Publication
Biological Process nucleolar large rRNA transcription by RNA polymerase IIBA:GO_Central1 Publication
Biological Process RNA polymerase I preinitiation complex assemblyIDA:UniProtKB1 Publication

Cellular Location

Nucleus, nucleolus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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