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Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1955) (CBMAB-T1041-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAOK3 (TAO Kinase 3). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TAOK3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1955
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa809-899 from human TAOK3 (AAH02756) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 809-899

Target

Full Name
TAO kinase 3
Introduction
TAOK3 is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. TAOK3 is a member of the GCK subfamily of STE20-like kinases.
Entrez Gene ID
51347
UniProt ID
Q9H2K8
Alternative Names
TAO Kinase 3; Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-09; Dendritic Cell-Derived Protein Kinase; Thousand And One Amino Acid Protein 3; CTCL-Associated Antigen HD-CL-09; Kinase From Chicken Homolog A; Jun Kinase-Inhibitory Kinase; JNK/SAPK-Inhibitory Kinase; EC 2.7.11.1
Function
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Biological Process
Biological Process cellular response to DNA damage stimulusIDA:UniProtKB1 Publication
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process intracellular signal transductionIBA:GO_Central1 Publication
Biological Process MAPK cascadeIMP:HGNC-UCL1 Publication
Biological Process mitotic G2 DNA damage checkpoint signalingIMP:UniProtKB1 Publication
Biological Process negative regulation of JNK cascadeIDA:HGNC-UCL1 Publication
Biological Process neuron projection morphogenesisIBA:GO_Central1 Publication
Biological Process positive regulation of JNK cascadeIMP:HGNC-UCL1 Publication
Biological Process positive regulation of JUN kinase activityIMP:UniProtKB1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeIMP:UniProtKB1 Publication
Biological Process protein autophosphorylationIDA:HGNC-UCL1 Publication
Biological Process protein phosphorylationIDA:HGNC-UCL1 Publication
Biological Process regulation of MAPK cascadeIBA:GO_Central1 Publication
Cellular Location
Cytoplasm
Cell membrane
Also localized to the peripheral cell membrane.
PTM
Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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