Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1955) (CBMAB-T1041-YJ)

Name: Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1955)
SKU: CBMAB-T1041-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-1955

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa809-899 from human TAOK3 (AAH02756) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 809-899

More Infomation

Target

Full Name

TAO kinase 3

Introduction

TAOK3 is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. TAOK3 is a member of the GCK subfamily of STE20-like kinases.

Entrez Gene ID

51347

UniProt ID

Q9H2K8

Alternative Names

TAO Kinase 3; Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-09; Dendritic Cell-Derived Protein Kinase; Thousand And One Amino Acid Protein 3; CTCL-Associated Antigen HD-CL-09; Kinase From Chicken Homolog A; Jun Kinase-Inhibitory Kinase; JNK/SAPK-Inhibitory Kinase; EC 2.7.11.1

Function

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

Biological Process

Biological Process cellular response to DNA damage stimulusIDA:UniProtKB1 Publication
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process intracellular signal transductionIBA:GO_Central1 Publication
Biological Process MAPK cascadeIMP:HGNC-UCL1 Publication
Biological Process mitotic G2 DNA damage checkpoint signalingIMP:UniProtKB1 Publication
Biological Process negative regulation of JNK cascadeIDA:HGNC-UCL1 Publication
Biological Process neuron projection morphogenesisIBA:GO_Central1 Publication
Biological Process positive regulation of JNK cascadeIMP:HGNC-UCL1 Publication
Biological Process positive regulation of JUN kinase activityIMP:UniProtKB1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeIMP:UniProtKB1 Publication
Biological Process protein autophosphorylationIDA:HGNC-UCL1 Publication
Biological Process protein phosphorylationIDA:HGNC-UCL1 Publication
Biological Process regulation of MAPK cascadeIBA:GO_Central1 Publication

Cellular Location

Cytoplasm
Cell membrane
Also localized to the peripheral cell membrane.

PTM

Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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