loading...

TAOK3

TAOK3 is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. TAOK3 is a member of the GCK subfamily of STE20-like kinases.

Full Name

TAO kinase 3

Function

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

Biological Process

Biological Process cellular response to DNA damage stimulusIDA:UniProtKB1 Publication
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process intracellular signal transductionIBA:GO_Central1 Publication
Biological Process MAPK cascadeIMP:HGNC-UCL1 Publication
Biological Process mitotic G2 DNA damage checkpoint signalingIMP:UniProtKB1 Publication
Biological Process negative regulation of JNK cascadeIDA:HGNC-UCL1 Publication
Biological Process neuron projection morphogenesisIBA:GO_Central1 Publication
Biological Process positive regulation of JNK cascadeIMP:HGNC-UCL1 Publication
Biological Process positive regulation of JUN kinase activityIMP:UniProtKB1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeIMP:UniProtKB1 Publication
Biological Process protein autophosphorylationIDA:HGNC-UCL1 Publication
Biological Process protein phosphorylationIDA:HGNC-UCL1 Publication
Biological Process regulation of MAPK cascadeIBA:GO_Central1 Publication

Cellular Location

Cytoplasm
Cell membrane
Also localized to the peripheral cell membrane.

PTM

Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.

View more

Anti-TAOK3 antibodies

+ Filters

Loading...

Mouse Anti-TAOK3 Recombinant Antibody (4C12) (CBMAB-A8870-LY)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4C12

Application*: WB, E

Mouse Anti-TAOK3 Recombinant Antibody (4A2) (CBMAB-A8869-LY)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4A2

Application*: WB, E

Mouse Anti-TAOK3 Recombinant Antibody (3D11) (CBMAB-A8868-LY)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3D11

Application*: WB, E

Mouse Anti-TAOK3 Recombinant Antibody (3B2) (CBMAB-A8867-LY)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3B2

Application*: WB, E

Mouse Anti-TAOK3 Recombinant Antibody (2B8) (CBMAB-A8866-LY)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2B8

Application*: WB, E

Mouse Anti-TAOK3 Recombinant Antibody (1D8) (CBMAB-A8865-LY)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D8

Application*: WB, E

Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1956) (CBMAB-T1042-YJ)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-1956

Application*: E, WB

Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1955) (CBMAB-T1041-YJ)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-1955

Application*: E, WB

Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1954) (CBMAB-T1040-YJ)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1954

Application*: E, WB

Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1953) (CBMAB-T1039-YJ)

Compare

Target: TAOK3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-1953

Application*: E, IF, WB

Human Recombinant TAOK3, Active protein, GST Tag (V2LY-0526-LY7056)

Compare

Target: TAOK3

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-463

Tag: GST Tag

Human Recombinant TAOK3 protein, GST Tag (V2LY-0526-LY7055)

Compare

Target: TAOK3

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-411

Tag: GST Tag

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry