TAOK3

TAOK3 is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. TAOK3 is a member of the GCK subfamily of STE20-like kinases.
Full Name
TAO kinase 3
Function
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Biological Process
Biological Process cellular response to DNA damage stimulusIDA:UniProtKB1 Publication
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process intracellular signal transductionIBA:GO_Central1 Publication
Biological Process MAPK cascadeIMP:HGNC-UCL1 Publication
Biological Process mitotic G2 DNA damage checkpoint signalingIMP:UniProtKB1 Publication
Biological Process negative regulation of JNK cascadeIDA:HGNC-UCL1 Publication
Biological Process neuron projection morphogenesisIBA:GO_Central1 Publication
Biological Process positive regulation of JNK cascadeIMP:HGNC-UCL1 Publication
Biological Process positive regulation of JUN kinase activityIMP:UniProtKB1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeIMP:UniProtKB1 Publication
Biological Process protein autophosphorylationIDA:HGNC-UCL1 Publication
Biological Process protein phosphorylationIDA:HGNC-UCL1 Publication
Biological Process regulation of MAPK cascadeIBA:GO_Central1 Publication
Cellular Location
Cytoplasm
Cell membrane
Also localized to the peripheral cell membrane.
PTM
Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.
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Anti-TAOK3 antibodies

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Mouse Anti-TAOK3 Recombinant Antibody (4C12) (CBMAB-A8870-LY)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C12
Application*: WB, E
Datasheet SDS

Mouse Anti-TAOK3 Recombinant Antibody (4A2) (CBMAB-A8869-LY)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A2
Application*: WB, E
Datasheet SDS

Mouse Anti-TAOK3 Recombinant Antibody (3D11) (CBMAB-A8868-LY)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D11
Application*: WB, E
Datasheet SDS

Mouse Anti-TAOK3 Recombinant Antibody (3B2) (CBMAB-A8867-LY)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B2
Application*: WB, E
Datasheet SDS

Mouse Anti-TAOK3 Recombinant Antibody (2B8) (CBMAB-A8866-LY)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B8
Application*: WB, E
Datasheet SDS

Mouse Anti-TAOK3 Recombinant Antibody (1D8) (CBMAB-A8865-LY)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D8
Application*: WB, E
Datasheet SDS

Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1956) (CBMAB-T1042-YJ)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-1956
Application*: E, WB
Datasheet SDS

Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1955) (CBMAB-T1041-YJ)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-1955
Application*: E, WB
Datasheet SDS

Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1954) (CBMAB-T1040-YJ)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-1954
Application*: E, WB
Datasheet SDS

Mouse Anti-TAOK3 Recombinant Antibody (CBYJT-1953) (CBMAB-T1039-YJ)

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Target: TAOK3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1953
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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