Human Recombinant TAOK3, Active protein, GST Tag (V2LY-0526-LY7056)

Name: Human Recombinant TAOK3, Active protein, GST Tag
SKU: V2LY-0526-LY7056
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant TAOK3, Active protein, GST Tag consist of Amino Acid: 1-463 and predicts a molecular mass of 89 kDa.

Molecule Mass

89 kDa

Sequence

Amino Acid: 1-463

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

TAO kinase 3

Function

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

Biological Process

Biological Process cellular response to DNA damage stimulusIDA:UniProtKB1 Publication
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process intracellular signal transductionIBA:GO_Central1 Publication
Biological Process MAPK cascadeIMP:HGNC-UCL1 Publication
Biological Process mitotic G2 DNA damage checkpoint signalingIMP:UniProtKB1 Publication
Biological Process negative regulation of JNK cascadeIDA:HGNC-UCL1 Publication
Biological Process neuron projection morphogenesisIBA:GO_Central1 Publication
Biological Process positive regulation of JNK cascadeIMP:HGNC-UCL1 Publication
Biological Process positive regulation of JUN kinase activityIMP:UniProtKB1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeIMP:UniProtKB1 Publication
Biological Process protein autophosphorylationIDA:HGNC-UCL1 Publication
Biological Process protein phosphorylationIDA:HGNC-UCL1 Publication
Biological Process regulation of MAPK cascadeIBA:GO_Central1 Publication

Cellular Location

Cytoplasm
Cell membrane
Also localized to the peripheral cell membrane.

PTM

Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TAOK3 protein, GST Tag (CAT#: V2LY-0526-LY7055)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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