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Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1970) (CBMAB-T1058-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAPBPL (TAP Binding Protein Like). The antibody can be used for immunoassay techniques, such as WB, IHC.
See all TAPBPL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1970
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human TAPBPL(NP_060479) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TAPBPL Gene(Protein Coding) TAP Binding Protein Like
Introduction
Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.
Entrez Gene ID
55080
UniProt ID
Q9BX59
Alternative Names
TAP Binding Protein Like; TAP-Binding Protein-Related Protein; Tapasin-Like; TAPASIN-R; TAPBP-R; TAP Binding Protein Related
Function
Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).
Biological Process
Biological Process negative regulation of antigen processing and presentation of peptide antigen via MHC class IIDA:UniProtKB1 Publication
Biological Process peptide antigen assembly with MHC class I protein complexIDA:UniProtKB1 Publication
Biological Process regulation of immune responseIBA:GO_Central1 Publication
Cellular Location
Cell membrane
Endoplasmic reticulum membrane
Microsome membrane
Golgi apparatus membrane
Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).
Topology
Lumenal: 19-405
Helical: 406-426
Cytoplasmic: 427-468
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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