Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1972) (CBMAB-T1060-YJ)

Name: Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1972)
SKU: CBMAB-T1060-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-1972

Application

WB, IHC

Immunogen

Full length human recombinant protein of human TAPBPL(NP_060479) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TAPBPL Gene(Protein Coding) TAP Binding Protein Like

Introduction

Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.

Entrez Gene ID

55080

UniProt ID

Q9BX59

Alternative Names

TAP Binding Protein Like; TAP-Binding Protein-Related Protein; Tapasin-Like; TAPASIN-R; TAPBP-R; TAP Binding Protein Related

Function

Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).

Biological Process

Biological Process negative regulation of antigen processing and presentation of peptide antigen via MHC class IIDA:UniProtKB1 Publication
Biological Process peptide antigen assembly with MHC class I protein complexIDA:UniProtKB1 Publication
Biological Process regulation of immune responseIBA:GO_Central1 Publication

Cellular Location

Cell membrane
Endoplasmic reticulum membrane
Microsome membrane
Golgi apparatus membrane
Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).

Topology

Lumenal: 19-405
Helical: 406-426
Cytoplasmic: 427-468

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TAPBPL Matched Antibody Pair (1183) (CAT#: APMAB-1183LY)

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Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1970) (CAT#: CBMAB-T1058-YJ)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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