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TAPBPL

Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]
Full Name
TAPBPL Gene(Protein Coding) TAP Binding Protein Like
Function
Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).
Biological Process
Biological Process negative regulation of antigen processing and presentation of peptide antigen via MHC class IIDA:UniProtKB1 Publication
Biological Process peptide antigen assembly with MHC class I protein complexIDA:UniProtKB1 Publication
Biological Process regulation of immune responseIBA:GO_Central1 Publication
Cellular Location
Cell membrane
Endoplasmic reticulum membrane
Microsome membrane
Golgi apparatus membrane
Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).
Topology
Lumenal: 19-405
Helical: 406-426
Cytoplasmic: 427-468

Anti-TAPBPL antibodies

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Mouse Anti-TAPBPL Recombinant Antibody (6E3) (CBMAB-A8875-LY)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6E3
Application*: WB, E

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1970) (CBMAB-T1058-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1970
Application*: WB, IH

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1971) (CBMAB-T1059-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-1971
Application*: WB

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1972) (CBMAB-T1060-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1972
Application*: WB, IH

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1973) (CBMAB-T1061-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1973
Application*: WB

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1974) (CBMAB-T1062-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1974
Application*: P, WB

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1975) (CBMAB-T1063-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1975
Application*: WB, IH, IF

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1976) (CBMAB-T1064-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1976
Application*: WB, IH

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1977) (CBMAB-T1065-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1977
Application*: P, WB

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1978) (CBMAB-T1066-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1978
Application*: E, WB

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1979) (CBMAB-T1067-YJ)

Datasheet SDS
Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: CBYJT-1979
Application*: WB, IH, IF

TAPBPL Matched Antibody Pair (1183) (APMAB-1183LY)

Datasheet SDS
Target: TAPBPL
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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