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TAPBPL

Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]
Full Name
TAPBPL Gene(Protein Coding) TAP Binding Protein Like
Function
Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).
Biological Process
Biological Process negative regulation of antigen processing and presentation of peptide antigen via MHC class IIDA:UniProtKB1 Publication
Biological Process peptide antigen assembly with MHC class I protein complexIDA:UniProtKB1 Publication
Biological Process regulation of immune responseIBA:GO_Central1 Publication
Cellular Location
Cell membrane
Endoplasmic reticulum membrane
Microsome membrane
Golgi apparatus membrane
Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).
Topology
Lumenal: 19-405
Helical: 406-426
Cytoplasmic: 427-468
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Anti-TAPBPL antibodies

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Mouse Anti-TAPBPL Recombinant Antibody (6E3) (CBMAB-A8875-LY)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6E3
Application*: WB, E
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1979) (CBMAB-T1067-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: CBYJT-1979
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1978) (CBMAB-T1066-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1978
Application*: E, WB
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1977) (CBMAB-T1065-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1977
Application*: P, WB
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1976) (CBMAB-T1064-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1976
Application*: WB, IH
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1975) (CBMAB-T1063-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1975
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1974) (CBMAB-T1062-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1974
Application*: P, WB
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1973) (CBMAB-T1061-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1973
Application*: WB
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1972) (CBMAB-T1060-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1972
Application*: WB, IH
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1971) (CBMAB-T1059-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-1971
Application*: WB
Datasheet SDS

Mouse Anti-TAPBPL Recombinant Antibody (CBYJT-1970) (CBMAB-T1058-YJ)

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Target: TAPBPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1970
Application*: WB, IH
Datasheet SDS

TAPBPL Matched Antibody Pair (1183) (APMAB-1183LY)

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Target: TAPBPL
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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