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Mouse Anti-TBCK Recombinant Antibody (CBYJT-2081) (CBMAB-T1178-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBCK (TBC1 Domain Containing Kinase). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all TBCK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2081
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 601-701

Target

Full Name
TBC1 Domain Containing Kinase
Introduction
TBCK is a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. TBCK is thought to function in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. TBCK may also be involved in the transcriptional regulation of the components of the mTOR complex.
Entrez Gene ID
93627
UniProt ID
Q8TEA7
Alternative Names
TBC1 Domain Containing Kinase; TBCKL; TBC Domain-Containing Protein Kinase-Like Protein; HSPC302; IHPRF3
Function
Involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:27040691, PubMed:23977024).
Involved in the regulation of cell proliferation and growth (PubMed:23977024, PubMed:24576458).
Involved in the control of actin-cytoskeleton organization (PubMed:23977024).
Biological Process
Biological Process actin cytoskeleton organizationIMP:UniProtKB1 Publication
Biological Process activation of GTPase activityIBA:GO_Central1 Publication
Biological Process cell population proliferationIMP:UniProtKB1 Publication
Biological Process regulation of TOR signalingIMP:UniProtKB1 Publication
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton, spindle
Midbody
Mainly localized in the cytoplasm during interphase. During metaphase, TBCK accumulates at the mitotic spindle. At the end of mitosis, it is detected at the midbody.
Involvement in disease
Hypotonia, infantile, with psychomotor retardation and characteristic facies 3 (IHPRF3):
An autosomal recessive neurodevelopmental disorder characterized by profound developmental disability, intellectual disability and severe hypotonia. Many patients have seizures, and show brain atrophy, dysgenesis of the corpus callosum and white-matter changes on neuroimaging. Non-specific facial dysmorphism is noted in some individuals.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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