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Mouse Anti-TBL1X Recombinant Antibody (CBT1186) (V2LY-0625-LY2963)


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Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
CBT1186
Antibody Isotype
IgG
Application
WB, ELISA

Basic Information

Immunogen
Purified recombinant fragment of human TBL1X expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
BSA, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
transducin beta like 1 X-linked
Entrez Gene ID
6907
Research Area
Epigenetics and nuclear signaling; Cancer; Metabolism
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219).
Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272).
Biological Process
Fat cell differentiation
Negative regulation of transcription by RNA polymerase II
Positive regulation of canonical Wnt signaling pathway
Positive regulation of DNA-templated transcription
Positive regulation of transcription by RNA polymerase II
Proteasome-mediated ubiquitin-dependent protein catabolic process
Protein stabilization
Proteolysis
Regulation of transcription by RNA polymerase II
Response to estrogen
Response to steroid hormone
Sensory perception of sound
Cellular Location
Nucleus
Note: Colocalized with MECP2 to the heterochromatin foci.
Involvement in disease
Hypothyroidism, congenital, non-goitrous, 8 (CHNG8):
A form of central hypothyroidism, a disorder characterized by sub-optimal thyroid hormone secretion, due to insufficient stimulation by the thyroid stimulating hormone of an otherwise normal thyroid gland. It may be caused by congenital or acquired disorders of the pituitary gland or hypothalamus. CHNG8 is a congenital, X-linked, relatively mild form which may be accompanied by hearing loss in some patients.
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For research use only. Not intended for any clinical use.

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