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TBL1X

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
Full Name
transducin beta like 1 X-linked
Research Area
Epigenetics and nuclear signaling; Cancer; Metabolism
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219).
Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272).
Biological Process
Fat cell differentiation
Negative regulation of transcription by RNA polymerase II
Positive regulation of canonical Wnt signaling pathway
Positive regulation of DNA-templated transcription
Positive regulation of transcription by RNA polymerase II
Proteasome-mediated ubiquitin-dependent protein catabolic process
Protein stabilization
Proteolysis
Regulation of transcription by RNA polymerase II
Response to estrogen
Response to steroid hormone
Sensory perception of sound
Cellular Location
Nucleus
Note: Colocalized with MECP2 to the heterochromatin foci.
Involvement in disease
Hypothyroidism, congenital, non-goitrous, 8 (CHNG8):
A form of central hypothyroidism, a disorder characterized by sub-optimal thyroid hormone secretion, due to insufficient stimulation by the thyroid stimulating hormone of an otherwise normal thyroid gland. It may be caused by congenital or acquired disorders of the pituitary gland or hypothalamus. CHNG8 is a congenital, X-linked, relatively mild form which may be accompanied by hearing loss in some patients.
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Anti-TBL1X antibodies

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Mouse Anti-TBL1X Recombinant Antibody (CBT1186) (V2LY-0625-LY2963)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBT1186
Application*: WB, E
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (4G1) (CBMAB-AO1004LY)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 4G1
Application*: WB
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (2B6) (CBMAB-A8900-LY)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B6
Application*: IH, E
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (CBYJT-2096) (CBMAB-T1195-YJ)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-2096
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (CBYJT-2095) (CBMAB-T1194-YJ)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-2095
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (CBYJT-2094) (CBMAB-T1193-YJ)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYJT-2094
Application*: WB, E
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (CBYJT-2093) (CBMAB-T1192-YJ)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYJT-2093
Application*: E, WB
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (CBYJT-2091) (CBMAB-T1190-YJ)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2091
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (4H2-D5-E9) (CBMAB-T1189-YJ)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4H2-D5-E9
Application*: WB, IC
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (CBYJT-2090) (CBMAB-T1188-YJ)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2090
Application*: IC, WB
Datasheet SDS

Mouse Anti-TBL1X Recombinant Antibody (CBYJT-2089) (CBMAB-T1187-YJ)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2089
Application*: E, IH
Datasheet SDS

Mouse Anti-TBL1X Monoclonal Antibody (2C3) (CBMAB-0223-LY)

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Target: TBL1X
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C3
Application*: IP, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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