Mouse Anti-TBL1X Recombinant Antibody (CBYJT-2089) (CBMAB-T1187-YJ)

Name: Mouse Anti-TBL1X Recombinant Antibody (CBYJT-2089)
SKU: CBMAB-T1187-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2089

Application

ELISA, IHC

Immunogen

Partial recombinant corresponding to aa478-578 from human TBL1X (NP_005638) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 478-578

More Infomation

Target

Full Name

transducin beta like 1 X-linked

Introduction

TBL1X has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may function in the control of cytotypic differentiation. TBL1X is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein.

Entrez Gene ID

6907

UniProt ID

O60907

Alternative Names

Transducin Beta Like 1 X-Linked; Transducin-Beta-Like Protein 1, X-Linked; Transducin Beta-Like Protein 1X; Transducin Beta Like 1X-Linked; SMAP55; TBL1

Research Area

Epigenetics and nuclear signaling; Cancer; Metabolism

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219).
Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272).

Biological Process

Fat cell differentiation
Negative regulation of transcription by RNA polymerase II
Positive regulation of canonical Wnt signaling pathway
Positive regulation of DNA-templated transcription
Positive regulation of transcription by RNA polymerase II
Proteasome-mediated ubiquitin-dependent protein catabolic process
Protein stabilization
Proteolysis
Regulation of transcription by RNA polymerase II
Response to estrogen
Response to steroid hormone
Sensory perception of sound

Cellular Location

Nucleus
Note: Colocalized with MECP2 to the heterochromatin foci.

Involvement in disease

Hypothyroidism, congenital, non-goitrous, 8 (CHNG8):
A form of central hypothyroidism, a disorder characterized by sub-optimal thyroid hormone secretion, due to insufficient stimulation by the thyroid stimulating hormone of an otherwise normal thyroid gland. It may be caused by congenital or acquired disorders of the pituitary gland or hypothalamus. CHNG8 is a congenital, X-linked, relatively mild form which may be accompanied by hearing loss in some patients.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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