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Rabbit Anti-TCAP Recombinant Antibody (CBYJT-2212) (CBMAB-T1318-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TCAP (Titin-Cap). The antibody can be used for immunoassay techniques, such as WB, IP, ICC, IF.
See all TCAP antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Rat, Mouse
Clone
CBYJT-2212
Antibody Isotype
IgG
Application
WB, IP, ICC, IF

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the C terminus of Human Telethonin (UniProt O15273).
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
titin-cap (telethonin)
Introduction
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. TCAP is a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in TCAP are associated with limb-girdle muscular dystrophy type 2G.
Entrez Gene ID
Human8557
Mouse21393
Rat688173
UniProt ID
HumanO15273
MouseO70548
RatA6HIS0
Alternative Names
Titin-Cap; Limb Girdle Muscular Dystrophy 2G (Autosomal Recessive); Teneurin C-Terminal Associated Peptide; 19 KDa Sarcomeric Protein; Titin Cap Protein; Titin-Cap (Telethonin); Telethonin
Function
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
Biological Process
Biological Process adult heart developmentIMP:BHF-UCL1 Publication
Biological Process cardiac muscle cell developmentIMP:BHF-UCL1 Publication
Biological Process cardiac muscle contractionIMP:BHF-UCL2 Publications
Biological Process cardiac muscle hypertrophyIMP:BHF-UCL1 Publication
Biological Process cardiac muscle hypertrophy in response to stressIMP:BHF-UCL1 Publication
Biological Process cardiac muscle tissue morphogenesisIMP:BHF-UCL1 Publication
Biological Process cardiac myofibril assemblyIMP:BHF-UCL1 Publication
Biological Process detection of mechanical stimulusTAS:BHF-UCL1 Publication
Biological Process detection of muscle stretchIMP:BHF-UCL1 Publication
Biological Process otic vesicle formationIEA:Ensembl
Biological Process protein-containing complex assemblyTAS:ProtInc1 Publication
Biological Process response to muscle stretchTAS:BHF-UCL1 Publication
Biological Process sarcomere organizationIMP:BHF-UCL1 Publication
Biological Process sarcomerogenesisIMP:BHF-UCL1 Publication
Biological Process skeletal muscle contractionIEP:BHF-UCL1 Publication
Biological Process skeletal muscle myosin thick filament assemblyIMP:BHF-UCL1 Publication
Biological Process skeletal muscle thin filament assemblyIMP:BHF-UCL1 Publication
Biological Process somitogenesisIEA:Ensembl
Cellular Location
Cytoplasm, myofibril, sarcomere
Involvement in disease
Cardiomyopathy, familial hypertrophic 25 (CMH25):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Muscular dystrophy, limb-girdle, autosomal recessive 7 (LGMDR7):
An autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle biopsy, and absence of telethonin. Cardiac muscle is involved in a subset of patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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