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Mouse Anti-Tcap Recombinant Antibody (CBYJT-2213) (CBMAB-T1319-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Tcap (Titin-Cap). The antibody can be used for immunoassay techniques, such as WB.
See all Tcap antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human, Rat
Clone
CBYJT-2213
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Mouse Telethonin aa. 1-167
Specificity
Mouse, Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-167

Target

Full Name
titin-cap (telethonin)
Introduction
Tcap is a muscle assembly regulating factor. Tcap mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
Entrez Gene ID
Human8557
Mouse21393
Rat688173
UniProt ID
HumanO15273
MouseO70548
RatA6HIS0
Alternative Names
AI503981; AJ223855
Function
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
Biological Process
Biological Process adult heart developmentIMP:BHF-UCL1 Publication
Biological Process cardiac muscle cell developmentIMP:BHF-UCL1 Publication
Biological Process cardiac muscle contractionIMP:BHF-UCL2 Publications
Biological Process cardiac muscle hypertrophyIMP:BHF-UCL1 Publication
Biological Process cardiac muscle hypertrophy in response to stressIMP:BHF-UCL1 Publication
Biological Process cardiac muscle tissue morphogenesisIMP:BHF-UCL1 Publication
Biological Process cardiac myofibril assemblyIMP:BHF-UCL1 Publication
Biological Process detection of mechanical stimulusTAS:BHF-UCL1 Publication
Biological Process detection of muscle stretchIMP:BHF-UCL1 Publication
Biological Process otic vesicle formationIEA:Ensembl
Biological Process protein-containing complex assemblyTAS:ProtInc1 Publication
Biological Process response to muscle stretchTAS:BHF-UCL1 Publication
Biological Process sarcomere organizationIMP:BHF-UCL1 Publication
Biological Process sarcomerogenesisIMP:BHF-UCL1 Publication
Biological Process skeletal muscle contractionIEP:BHF-UCL1 Publication
Biological Process skeletal muscle myosin thick filament assemblyIMP:BHF-UCL1 Publication
Biological Process skeletal muscle thin filament assemblyIMP:BHF-UCL1 Publication
Biological Process somitogenesisIEA:Ensembl
Cellular Location
Cytoplasm, myofibril, sarcomere
Involvement in disease
Cardiomyopathy, familial hypertrophic 25 (CMH25):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Muscular dystrophy, limb-girdle, autosomal recessive 7 (LGMDR7):
An autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle biopsy, and absence of telethonin. Cardiac muscle is involved in a subset of patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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