Mouse Anti-TCAP Recombinant Antibody (2B1) (CBMAB-A8929-LY)

Name: Mouse Anti-TCAP Recombinant Antibody (2B1)
SKU: CBMAB-A8929-LY
Rating: 5 (1 reviews)

See all TCAP antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2B1

Application

WB, ELISA

Immunogen

TCAP (AAH13330, 1 a.a. ~ 167 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

titin-cap (telethonin)

Introduction

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq]

Entrez Gene ID

8557

UniProt ID

O70548

Alternative Names

CMD1N; LGMD2G; T-cap; TELE; telethonin

Function

Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.

Biological Process

Biological Process adult heart developmentIMP:BHF-UCL1 Publication
Biological Process cardiac muscle cell developmentIMP:BHF-UCL1 Publication
Biological Process cardiac muscle contractionIMP:BHF-UCL2 Publications
Biological Process cardiac muscle hypertrophyIMP:BHF-UCL1 Publication
Biological Process cardiac muscle hypertrophy in response to stressIMP:BHF-UCL1 Publication
Biological Process cardiac muscle tissue morphogenesisIMP:BHF-UCL1 Publication
Biological Process cardiac myofibril assemblyIMP:BHF-UCL1 Publication
Biological Process detection of mechanical stimulusTAS:BHF-UCL1 Publication
Biological Process detection of muscle stretchIMP:BHF-UCL1 Publication
Biological Process otic vesicle formationIEA:Ensembl
Biological Process protein-containing complex assemblyTAS:ProtInc1 Publication
Biological Process response to muscle stretchTAS:BHF-UCL1 Publication
Biological Process sarcomere organizationIMP:BHF-UCL1 Publication
Biological Process sarcomerogenesisIMP:BHF-UCL1 Publication
Biological Process skeletal muscle contractionIEP:BHF-UCL1 Publication
Biological Process skeletal muscle myosin thick filament assemblyIMP:BHF-UCL1 Publication
Biological Process skeletal muscle thin filament assemblyIMP:BHF-UCL1 Publication
Biological Process somitogenesisIEA:Ensembl

Cellular Location

Cytoplasm, myofibril, sarcomere

Involvement in disease

Cardiomyopathy, familial hypertrophic 25 (CMH25):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Muscular dystrophy, limb-girdle, autosomal recessive 7 (LGMDR7):
An autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle biopsy, and absence of telethonin. Cardiac muscle is involved in a subset of patients.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-TCAP Recombinant Antibody (2B1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-TCAP Recombinant Antibody (CBYJT-2208) (CAT#: CBMAB-T1314-YJ)

Rabbit Anti-TCAP Recombinant Antibody (CBYJT-2212) (CAT#: CBMAB-T1318-YJ)

Mouse Anti-Tcap Recombinant Antibody (CBYJT-2213) (CAT#: CBMAB-T1319-YJ)

Mouse Anti-TCAP Recombinant Antibody (CBYJT-2206) (CAT#: CBMAB-T1312-YJ)

Mouse Anti-TCAP Recombinant Antibody (1H3) (CAT#: CBMAB-A8928-LY)

Mouse Anti-TCAP Recombinant Antibody (CBYJT-2207) (CAT#: CBMAB-T1313-YJ)

Mouse Anti-TCAP Recombinant Antibody (CBYJT-2204) (CAT#: CBMAB-T1310-YJ)

Mouse Anti-TCAP Recombinant Antibody (CBYJT-2209) (CAT#: CBMAB-T1315-YJ)

Mouse Anti-TCAP Recombinant Antibody (CBYJT-2210) (CAT#: CBMAB-T1316-YJ)

Mouse Anti-TCAP Recombinant Antibody (CBYJT-2205) (CAT#: CBMAB-T1311-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry