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Mouse Anti-TCF3 Recombinant Antibody (CBT2643) (V2LY-0625-LY2423)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2643
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human TCF3 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TCF3 Transcription Factor 3
Entrez Gene ID
6929
Function
Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity).
Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity).
Together with TCF15, required for the mesenchymal to epithelial transition (By similarity).
Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity).
Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990).
Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity).
Isoform E47
Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.
Biological Process
Biological Process B cell differentiationNAS:UniProtKB1 Publication
Biological Process B cell lineage commitmentIDA:UniProtKB1 Publication
Biological Process immunoglobulin V(D)J recombinationIDA:MGI1 Publication
Biological Process negative regulation of transcription by RNA polymerase IIIDA:NTNU_SB1 Publication
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of B cell proliferationIMP:UniProtKB
Biological Process positive regulation of cell cycleIDA:UniProtKB
Biological Process positive regulation of DNA-binding transcription factor activityIDA:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of neuron differentiationISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process regulation of DNA-templated transcriptionNAS:UniProtKB1 Publication
Biological Process regulation of G1/S transition of mitotic cell cycleIDA:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Agammaglobulinemia 8A, autosomal dominant (AGM8A):
A form of agammaglobulinemia, a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
PTM
Phosphorylated following NGF stimulation.
Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes.
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For research use only. Not intended for any clinical use.

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