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Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (V2LY-0625-LY657)


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Tested Data
Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (V2LY-0625-LY657) in ELISA
Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (V2LY-0625-LY657) in ELISA
Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (V2LY-0625-LY657) in WB
Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (V2LY-0625-LY657) in WB
Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (V2LY-0625-LY657) in WB
Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (V2LY-0625-LY657) in WB
Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (V2LY-0625-LY657) in FC
Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (V2LY-0625-LY657) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3091
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human TCF4 (AA: 518-667) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
transcription factor 4
Entrez Gene ID
6925
Function
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity).
Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB2 Publications
Biological Process positive regulation of neuron differentiationISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIISS:BHF-UCLBy Similarity
Biological Process protein-DNA complex assemblyISS:BHF-UCLBy Similarity
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Pitt-Hopkins syndrome (PTHS):
A syndrome characterized by intellectual disability, wide mouth and distinctive facial features, and intermittent hyperventilation followed by apnea. Features include intellectual disability with severe speech impairment, normal growth parameters at birth, postnatal microcephaly, breathing anomalies, severe motor developmental delay, motor incoordination, ocular anomalies, constipation, seizures, typical behavior and subtle brain abnormalities.
Corneal dystrophy, Fuchs endothelial, 3 (FECD3):
A late-onset form of Fuchs endothelial corneal dystrophy, a disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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