Rabbit Anti-TCF4 Recombinant Antibody (CBYJT-2267) (CBMAB-T1376-YJ)

Name: Rabbit Anti-TCF4 Recombinant Antibody (CBYJT-2267)
SKU: CBMAB-T1376-YJ
Rating: 5 (1 reviews)

See all TCF4 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBYJT-2267

Application

WB, IP

Immunogen

Detects endogenous levels of total human TCF4 protein. Species Sequence Homology: mouse and rat

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

10 mM HEPES, 150 mM NaCl, pH 7.5, 100 μg/mL BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

transcription factor 4

Introduction

TCF4 is transcription factor 4, a basic helix-loop-helix transcription factor. TCF4 recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. TCF4 is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to>50 repeat units and cause Fuchs endothelial corneal dystrophy.

Entrez Gene ID

6925

UniProt ID

P15884

Alternative Names

Transcription Factor 4; Class B Basic Helix-Loop-Helix Protein 19; Immunoglobulin Transcription Factor 2; SL3-3 Enhancer Factor 2; BHLHb19; ITF-2; SEF-2; TCF-4; ITF2

Function

Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity).
Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.

Biological Process

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB2 Publications
Biological Process positive regulation of neuron differentiationISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIISS:BHF-UCLBy Similarity
Biological Process protein-DNA complex assemblyISS:BHF-UCLBy Similarity
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication

Cellular Location

Nucleus

Involvement in disease

Pitt-Hopkins syndrome (PTHS):
A syndrome characterized by intellectual disability, wide mouth and distinctive facial features, and intermittent hyperventilation followed by apnea. Features include intellectual disability with severe speech impairment, normal growth parameters at birth, postnatal microcephaly, breathing anomalies, severe motor developmental delay, motor incoordination, ocular anomalies, constipation, seizures, typical behavior and subtle brain abnormalities.
Corneal dystrophy, Fuchs endothelial, 3 (FECD3):
A late-onset form of Fuchs endothelial corneal dystrophy, a disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-TCF4 Recombinant Antibody (CBYJT-2267)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TCF4 Recombinant Antibody (1G4) (CAT#: CBMAB-A8958-LY)

Mouse Anti-TCF4 Recombinant Antibody (CBYJT-2268) (CAT#: CBMAB-T1377-YJ)

Mouse Anti-TCF4 Recombinant Antibody (3H4) (CAT#: CBMAB-A8959-LY)

Mouse Anti-TCF4 Recombinant Antibody (CBYJT-2264) (CAT#: CBMAB-T1373-YJ)

Mouse Anti-TCF4 Recombinant Antibody (CBT3091) (CAT#: V2LY-0625-LY657)

Mouse Anti-TCF4 Recombinant Antibody (CBYJT-2265) (CAT#: CBMAB-T1374-YJ)

Rabbit Anti-TCF4 Recombinant Antibody (CBYJT-2271) (CAT#: CBMAB-T1380-YJ)

Mouse Anti-TCF4 Recombinant Antibody (CBYJT-2270) (CAT#: CBMAB-T1379-YJ)

Mouse Anti-TCF4 Recombinant Antibody (CBT2789) (CAT#: V2LY-0625-LY656)

Mouse Anti-TCF4 Recombinant Antibody (1F6) (CAT#: CBMAB-A8957-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry