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Rabbit Anti-TCF7 Recombinant Antibody (CBYJT-2280) (CBMAB-T1389-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TCF7 (Transcription Factor 7). The antibody can be used for immunoassay techniques, such as FC, ICC, IF, IHC-P, IP, WB.
See all TCF7 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYJT-2280
Antibody Isotype
IgG
Application
FC, ICC, IF, IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to a region surrounding Pro95 of human TCF1 protein
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
10 mM HEPES, 150 mM NaCl, pH 7.5, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Residues surrounding Pro95

Target

Full Name
TCF7 Gene(Protein Coding) Transcription Factor 7
Introduction
TCF7 is a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. TCF7 is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. TCF7 forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation.
Entrez Gene ID
Human6932
Mouse21414
UniProt ID
HumanP36402
MouseQ00417
Alternative Names
Transcription Factor 7; Transcription Factor 7 (T-Cell Specific, HMG-Box); T-Cell-Specific Transcription Factor 1; T-Cell-Factor-7; TCF-1; T-Cell Factor 1; TCF-7; TCF1
Function
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity).
Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity).
TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
Biological Process
Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process cellular response to interleukin-4IDA:UniProtKB1 Publication
Biological Process gamma-delta T cell differentiationISS:UniProtKB
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of gamma-delta T cell differentiationISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process T cell receptor V(D)J recombinationIEA:InterPro
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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