TCF7

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

TCF7 Gene(Protein Coding) Transcription Factor 7

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity).
Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity).
TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process cellular response to interleukin-4IDA:UniProtKB1 Publication
Biological Process gamma-delta T cell differentiationISS:UniProtKB
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of gamma-delta T cell differentiationISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process T cell receptor V(D)J recombinationIEA:InterPro

Nucleus