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Rat Anti-Tcf7 Recombinant Antibody (CBYJT-2283) (CBMAB-T1392-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tcf7 (Transcription Factor 7, T Cell Specific). The antibody can be used for immunoassay techniques, such as FC, WB.
See all Tcf7 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-2283
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse TCF-7
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TCF7 Gene(Protein Coding) Transcription Factor 7
Introduction
Tcf7 is a transcription factor which is a member of the T-cell specific transcription factor family. Tcf7 is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1.
Entrez Gene ID
21414
UniProt ID
Q00417
Alternative Names
Tcf1; TCF-1; AI465550
Function
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity).
Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity).
TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
Biological Process
Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process cellular response to interleukin-4IDA:UniProtKB1 Publication
Biological Process gamma-delta T cell differentiationISS:UniProtKB
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of gamma-delta T cell differentiationISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process T cell receptor V(D)J recombinationIEA:InterPro
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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