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Mouse Anti-TCF7 Recombinant Antibody (1B3) (CBMAB-A8961-LY)

The product is antibody recognizes TCF7. The antibody 1B3 immunoassay techniques such as: WB, ELISA.
See all TCF7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TCF7 (NP_003193, 287 a.a. ~ 384 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TCF7 Gene(Protein Coding) Transcription Factor 7
Entrez Gene ID
6932
UniProt ID
P36402
Alternative Names
FLJ36364; MGC47735; TCF-1
Function
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity).
Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity).
TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
Biological Process
Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process cellular response to interleukin-4IDA:UniProtKB1 Publication
Biological Process gamma-delta T cell differentiationISS:UniProtKB
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of gamma-delta T cell differentiationISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process T cell receptor V(D)J recombinationIEA:InterPro
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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