Mouse Anti-TCF7 Recombinant Antibody (CBYJT-2277) (CBMAB-T1386-YJ)

Name: Mouse Anti-TCF7 Recombinant Antibody (CBYJT-2277)
SKU: CBMAB-T1386-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2277

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TCF7 Gene(Protein Coding) Transcription Factor 7

Introduction

TCF7 is a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. TCF7 is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. TCF7 forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation.

Entrez Gene ID

6932

UniProt ID

P36402

Alternative Names

Transcription Factor 7; Transcription Factor 7 (T-Cell Specific, HMG-Box); T-Cell-Specific Transcription Factor 1; T-Cell-Factor-7; TCF-1; T-Cell Factor 1; TCF-7; TCF1

Function

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity).
Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity).
TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

Biological Process

Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process cellular response to interleukin-4IDA:UniProtKB1 Publication
Biological Process gamma-delta T cell differentiationISS:UniProtKB
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of gamma-delta T cell differentiationISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process T cell receptor V(D)J recombinationIEA:InterPro

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TCF7 Matched Antibody Pair (1191) (CAT#: APMAB-1191LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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