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Mouse Anti-TEAD1 Recombinant Antibody (CBYJT-2469) (CBMAB-T1617-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TEAD1 (TEA Domain Transcription Factor 1). The antibody can be used for immunoassay techniques, such as Dot, WB.
See all TEAD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2469
Antibody Isotype
IgG1
Application
Dot, WB

Basic Information

Immunogen
Partial recombinant sequence from human TEA Domain Family Member 1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TEAD1 Gene(Protein Coding) TEA Domain Transcription Factor 1
Introduction
TEAD1 is a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. TEAD1 directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in TEAD1 cause Sveinsson's chorioretinal atrophy.
Entrez Gene ID
7003
UniProt ID
P28347
Alternative Names
TEA Domain Transcription Factor 1; TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor); Transcription Factor 13; Protein GT-IIC; NTEF-1; TCF-13; TEAD-1; TCF13; Atrophia Areata, Peripapillary Chorioretinal Degeneration
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Biological Process
Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process positive regulation of cell growthIDA:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcriptionIMP:CAFA1 Publication
Biological Process positive regulation of miRNA transcriptionIMP:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein-containing complex assemblyIMP:CAFA1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Sveinsson chorioretinal atrophy (SCRA):
Characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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