Mouse Anti-TEAD1 Recombinant Antibody (CBYJT-2475) (CBMAB-T1623-YJ)

Name: Mouse Anti-TEAD1 Recombinant Antibody (CBYJT-2475)
SKU: CBMAB-T1623-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2475

Application

WB, IF

Immunogen

Human TEF-1 aa. 86-199

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 86-199

More Infomation

Target

Full Name

TEAD1 Gene(Protein Coding) TEA Domain Transcription Factor 1

Introduction

TEAD1 is a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. TEAD1 directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in TEAD1 cause Sveinsson's chorioretinal atrophy.

Entrez Gene ID

Human	7003
Mouse	21676

UniProt ID

Human	P28347
Mouse	P30051

Alternative Names

TEA Domain Transcription Factor 1; TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor); Transcription Factor 13; Protein GT-IIC; NTEF-1; TCF-13; TEAD-1; TCF13; Atrophia Areata, Peripapillary Chorioretinal Degeneration

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Biological Process

Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process positive regulation of cell growthIDA:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcriptionIMP:CAFA1 Publication
Biological Process positive regulation of miRNA transcriptionIMP:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein-containing complex assemblyIMP:CAFA1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication

Cellular Location

Nucleus

Involvement in disease

Sveinsson chorioretinal atrophy (SCRA):
Characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-TEAD1 Recombinant Antibody (CBYJT-2469) (CAT#: CBMAB-T1617-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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