Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2482) (CBMAB-T1631-YJ)

Name: Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2482)
SKU: CBMAB-T1631-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-2482

Application

ELISA, WB

Immunogen

Partial recombinant mapping to a fragment of residues within aa151-261 from human TEAD4 with GST tag (NP_003204). MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 151-261

More Infomation

Target

Full Name

TEAD4 Gene(Protein Coding) TEA Domain Transcription Factor 4

Introduction

TEAD4 is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. TEAD4 is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression.

Entrez Gene ID

7004

UniProt ID

Q15561

Alternative Names

TEA Domain Transcription Factor 4; TEA Domain Family Member 4; Transcription Factor 13-Like 1; Transcription Factor RTEF-1; TCF13L1; RTEF1; TEF3; Transcriptional Enhancer Factor 1-Related; Related Transcription Enhancer Factor 1B

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

Biological Process

Biological Process cell fate specificationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Biological Process positive regulation of stem cell population maintenanceIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process skeletal system developmentTAS:ProtInc1 Publication
Biological Process trophectodermal cell fate commitmentIEA:Ensembl

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TEAD4 Matched Antibody Pair (1195) (CAT#: APMAB-1195LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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