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TEAD4

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Full Name
TEAD4 Gene(Protein Coding) TEA Domain Transcription Factor 4
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Biological Process
Biological Process cell fate specificationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Biological Process positive regulation of stem cell population maintenanceIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process skeletal system developmentTAS:ProtInc1 Publication
Biological Process trophectodermal cell fate commitmentIEA:Ensembl
Cellular Location
Nucleus
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Anti-TEAD4 antibodies

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TEAD4 Matched Antibody Pair (1195) (APMAB-1195LY)

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Target: TEAD4
Specificity: Human
Datasheet SDS

Mouse Anti-TEAD4 Recombinant Antibody (5H3) (CBMAB-A8993-LY)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5H3
Application*: WB, E
Datasheet SDS

Mouse Anti-TEAD4 Recombinant Antibody (1D10) (CBMAB-A8992-LY)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D10
Application*: WB, E
Datasheet SDS

Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2487) (CBMAB-T1636-YJ)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Mouse
Clone: CBYJT-2487
Application*: WB, CI, IC, IF
Datasheet SDS

Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2486) (CBMAB-T1635-YJ)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-2486
Application*: WB, P
Datasheet SDS

Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2485) (CBMAB-T1634-YJ)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2485
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2484) (CBMAB-T1633-YJ)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2484
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2483) (CBMAB-T1632-YJ)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-2483
Application*: E, WB
Datasheet SDS

Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2482) (CBMAB-T1631-YJ)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2482
Application*: E, WB
Datasheet SDS

Mouse Anti-TEAD4 Monoclonal Antibody (2F4) (CBMAB-0236-LY)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F4
Application*: IP, M, WB
Datasheet SDS

Mouse Anti-TEAD4 Monoclonal Antibody (1G7) (CBMAB-0235-LY)

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Target: TEAD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G7
Application*: IP, M, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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