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Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2487) (CBMAB-T1636-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TEAD4 (TEA Domain Transcription Factor 4). The antibody can be used for immunoassay techniques, such as WB, ChIP, ICC, IF.
See all TEAD4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-2487
Antibody Isotype
IgG2a
Application
WB, ChIP, ICC, IF

Basic Information

Immunogen
Recombinant fragment, corresponding to amino acids 151-261 of Human TEAD4
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 151-261

Target

Full Name
TEAD4 Gene(Protein Coding) TEA Domain Transcription Factor 4
Introduction
TEAD4 is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. TEAD4 is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression.
Entrez Gene ID
Human7004
Mouse21679
Rat683522
UniProt ID
HumanQ15561
MouseQ62296
RatF1M665
Alternative Names
TEA Domain Transcription Factor 4; TEA Domain Family Member 4; Transcription Factor 13-Like 1; Transcription Factor RTEF-1; TCF13L1; RTEF1; TEF3; Transcriptional Enhancer Factor 1-Related; Related Transcription Enhancer Factor 1B
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Biological Process
Biological Process cell fate specificationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Biological Process positive regulation of stem cell population maintenanceIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process skeletal system developmentTAS:ProtInc1 Publication
Biological Process trophectodermal cell fate commitmentIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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