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Mouse Anti-TENM1 Recombinant Antibody (CBYJT-2517) (CBMAB-T1670-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TENM1 (Teneurin Transmembrane Protein 1). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TENM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2517
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa2616-2725 from ODZ1 (NP_055068) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 2616-2725

Target

Full Name
Teneurin Transmembrane Protein 1
Introduction
TENM1 belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may play a role as a cellular signal transducer.
Entrez Gene ID
10178
UniProt ID
Q9UKZ4
Alternative Names
Teneurin Transmembrane Protein 1; Protein Odd Oz/Ten-M Homolog 1; TEN-M1; Ten-1; ODZ1; TNM1; Odz, Odd Oz/Ten-M Homolog 1 (Drosophila); Odz (Odd Oz/Ten-M, Drosophila) Homolog 3; Odz, Odd Oz/Ten-M Homolog 1(Drosophila)
Function
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).
Teneurin C-terminal-associated peptide
Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).
Ten-1 intracellular domain
Induces gene transcription activation.
Biological Process
Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesSource:GO_Central1 Publication
Biological Process immune responseSource:ProtInc1 Publication
Biological Process negative regulation of cell population proliferationSource:ProtInc1 Publication
Biological Process nervous system developmentSource:ProtInc1 Publication
Biological Process neuron developmentSource:GO_Central1 Publication
Biological Process neuropeptide signaling pathwaySource:UniProtKB-KW
Biological Process positive regulation of actin filament polymerizationSource:UniProtKB
Biological Process positive regulation of filopodium assemblySource:UniProtKB
Biological Process positive regulation of intracellular protein transportSource:UniProtKB
Biological Process positive regulation of MAP kinase activitySource:UniProtKB
Biological Process positive regulation of peptidyl-serine phosphorylationSource:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIISource:UniProtKB
Cellular Location
Cell membrane
Ten-1 intracellular domain
Nucleus
Nucleus speckle
Nucleus matrix
Cytoplasm, cytoskeleton
Teneurin C-terminal-associated peptide
Nucleus
Cytoplasm
Cell membrane
Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity).
Topology
Cytoplasmic: 1-324
Helical: 325-345
Extracellular: 346-2725
PTM
Teneurin C-terminal-associated peptide
Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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