Mouse Anti-TENM1 Recombinant Antibody (CBYJT-2518) (CBMAB-T1671-YJ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Teneurin C-terminal-associated peptide
Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).
Ten-1 intracellular domain
Induces gene transcription activation.
Biological Process immune responseSource:ProtInc1 Publication
Biological Process negative regulation of cell population proliferationSource:ProtInc1 Publication
Biological Process nervous system developmentSource:ProtInc1 Publication
Biological Process neuron developmentSource:GO_Central1 Publication
Biological Process neuropeptide signaling pathwaySource:UniProtKB-KW
Biological Process positive regulation of actin filament polymerizationSource:UniProtKB
Biological Process positive regulation of filopodium assemblySource:UniProtKB
Biological Process positive regulation of intracellular protein transportSource:UniProtKB
Biological Process positive regulation of MAP kinase activitySource:UniProtKB
Biological Process positive regulation of peptidyl-serine phosphorylationSource:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIISource:UniProtKB
Ten-1 intracellular domain
Nucleus
Nucleus speckle
Nucleus matrix
Cytoplasm, cytoskeleton
Teneurin C-terminal-associated peptide
Nucleus
Cytoplasm
Cell membrane
Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity).
Helical: 325-345
Extracellular: 346-2725
Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated (By similarity).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Related Products
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Mouse Anti-TENM1 Recombinant Antibody (3G8) (CAT#: CBMAB-A6211-LY)
Mouse Anti-TENM1 Recombinant Antibody (CBXO-0034) (CAT#: CBMAB-O0319-CQ)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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