TENM1

TENM1 belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may play a role as a cellular signal transducer.

Full Name

Teneurin Transmembrane Protein 1

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).
Teneurin C-terminal-associated peptide
Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).
Ten-1 intracellular domain
Induces gene transcription activation.

Biological Process

Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesSource:GO_Central1 Publication
Biological Process immune responseSource:ProtInc1 Publication
Biological Process negative regulation of cell population proliferationSource:ProtInc1 Publication
Biological Process nervous system developmentSource:ProtInc1 Publication
Biological Process neuron developmentSource:GO_Central1 Publication
Biological Process neuropeptide signaling pathwaySource:UniProtKB-KW
Biological Process positive regulation of actin filament polymerizationSource:UniProtKB
Biological Process positive regulation of filopodium assemblySource:UniProtKB
Biological Process positive regulation of intracellular protein transportSource:UniProtKB
Biological Process positive regulation of MAP kinase activitySource:UniProtKB
Biological Process positive regulation of peptidyl-serine phosphorylationSource:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIISource:UniProtKB

Cellular Location

Cell membrane
Ten-1 intracellular domain
Nucleus
Nucleus speckle
Nucleus matrix
Cytoplasm, cytoskeleton
Teneurin C-terminal-associated peptide
Nucleus
Cytoplasm
Cell membrane
Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity).

Topology

Cytoplasmic: 1-324
Helical: 325-345
Extracellular: 346-2725

PTM

Teneurin C-terminal-associated peptide
Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated (By similarity).