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Rat Anti-Tex19.1 Recombinant Antibody (CBYJT-2602) (CBMAB-T1772-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tex19.1 (Testis Expressed gene 19.1). The antibody can be used for immunoassay techniques, such as ICC.
See all Tex19.1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-2602
Antibody Isotype
IgG2a
Application
ICC

Basic Information

Immunogen
Recombinant corresponding to aa189-351 from mouse TEX19.1 expressed in E. coli (Q99MV2)
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 189-351

Target

Full Name
Testis Expressed gene 19.1
Introduction
Tex19.1 is required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and preventing their mobilization. With its paralog, Tex19.2, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Tex19.1 interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements.
Entrez Gene ID
73679
UniProt ID
Q99MV2
Alternative Names
Tex19; Tex19a; mTex19.1; 2410081M02Rik
Function
Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity).
Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172).
Biological Process
Biological Process cell differentiationSource:UniProtKB-KW
Biological Process male gonad developmentSource:GO_Central1 Publication
Biological Process male meiotic nuclear divisionSource:UniProtKB
Biological Process negative regulation of transpositionSource:UniProtKB1 Publication
Biological Process placenta developmentSource:GO_Central1 Publication
Biological Process reciprocal meiotic recombinationSource:UniProtKB
Biological Process spermatogenesisSource:UniProtKB
Cellular Location
Cytoplasm
Was initially reported to localize in the nucleus. However, it was later shown to localize in cytoplasm only. Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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