Rat Anti-Tex19.1 Recombinant Antibody (CBYJT-2604) (CBMAB-T1774-YJ)

Name: Rat Anti-Tex19.1 Recombinant Antibody (CBYJT-2604)
SKU: CBMAB-T1774-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBYJT-2604

Application

ICC

Immunogen

E. coli-derived recombinant mouse TEX19.1, Arg189-Pro351, Accession # Q99MV2

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 189-351

More Infomation

Target

Full Name

Testis Expressed gene 19.1

Introduction

Tex19.1 is required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and preventing their mobilization. With its paralog, Tex19.2, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Tex19.1 interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements.

Entrez Gene ID

73679

UniProt ID

Q99MV2

Alternative Names

Tex19; Tex19a; mTex19.1; 2410081M02Rik

Function

Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity).
Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172).

Biological Process

Biological Process cell differentiationSource:UniProtKB-KW
Biological Process male gonad developmentSource:GO_Central1 Publication
Biological Process male meiotic nuclear divisionSource:UniProtKB
Biological Process negative regulation of transpositionSource:UniProtKB1 Publication
Biological Process placenta developmentSource:GO_Central1 Publication
Biological Process reciprocal meiotic recombinationSource:UniProtKB
Biological Process spermatogenesisSource:UniProtKB

Cellular Location

Cytoplasm
Was initially reported to localize in the nucleus. However, it was later shown to localize in cytoplasm only. Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Rat Anti-Tex19.1 Recombinant Antibody (CBYJT-2603) (CAT#: CBMAB-T1773-YJ)

Rat Anti-Tex19.1 Recombinant Antibody (CBYJT-2602) (CAT#: CBMAB-T1772-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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