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Mouse Anti-TFB1M Recombinant Antibody (4E4) (CBMAB-A9034-LY)

The product is antibody recognizes TFB1M. The antibody 4E4 immunoassay techniques such as: WB, ELISA.
See all TFB1M antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TFB1M (AAH17788, 1 a.a. ~ 346 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TFB1M Gene(Protein Coding) Transcription Factor B1, Mitochondrial
Introduction
The transcription of genes from mitochondrial DNA requires a mitochondrial RNA polymerase (see POLRMT, MIM 601778) and a DNA-binding transcription factor (see TFAM, MIM 600438). Transcription factor B1 (TFB1M) is a part of this transcription complex.[supplied by OMIM
Entrez Gene ID
51106
UniProt ID
Q8WVM0
Alternative Names
CGI-75; CGI75; mtTFB; mtTFB1
Function
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
Biological Process
Biological Process rRNA methylationSource:GO_Central1 Publication
Biological Process rRNA modificationSource:Reactome
Biological Process transcription initiation at mitochondrial promoterSource:GO_Central1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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