TFB1M

The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]
Full Name
TFB1M Gene(Protein Coding) Transcription Factor B1, Mitochondrial
Function
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
Biological Process
Biological Process rRNA methylationSource:GO_Central1 Publication
Biological Process rRNA modificationSource:Reactome
Biological Process transcription initiation at mitochondrial promoterSource:GO_Central1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.
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Anti-TFB1M antibodies

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TFB1M Matched Antibody Pair (1197) (APMAB-1197LY)

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Target: TFB1M
Specificity: Human
Datasheet SDS

Mouse Anti-TFB1M Recombinant Antibody (4E4) (CBMAB-A9034-LY)

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Target: TFB1M
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E4
Application*: WB, E
Datasheet SDS

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2645) (CBMAB-T1824-YJ)

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Target: TFB1M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2645
Application*: WB
Datasheet SDS

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2643) (CBMAB-T1822-YJ)

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Target: TFB1M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2643
Application*: WB
Datasheet SDS

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2642) (CBMAB-T1821-YJ)

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Target: TFB1M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2642
Application*: WB
Datasheet SDS

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2641) (CBMAB-T1820-YJ)

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Target: TFB1M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2641
Application*: WB
Datasheet SDS

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2640) (CBMAB-T1819-YJ)

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Target: TFB1M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2640
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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