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TFB1M

The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]

Full Name

TFB1M Gene(Protein Coding) Transcription Factor B1, Mitochondrial

Function

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

Biological Process

Biological Process rRNA methylationSource:GO_Central1 Publication
Biological Process rRNA modificationSource:Reactome
Biological Process transcription initiation at mitochondrial promoterSource:GO_Central1 Publication

Cellular Location

Mitochondrion

Involvement in disease

Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.

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Anti-TFB1M antibodies

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TFB1M Matched Antibody Pair (1197) (APMAB-1197LY)

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Target: TFB1M

Specificity: Human

Mouse Anti-TFB1M Recombinant Antibody (4E4) (CBMAB-A9034-LY)

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Target: TFB1M

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4E4

Application*: WB, E

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2645) (CBMAB-T1824-YJ)

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Target: TFB1M

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2645

Application*: WB

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2643) (CBMAB-T1822-YJ)

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Target: TFB1M

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2643

Application*: WB

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2642) (CBMAB-T1821-YJ)

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Target: TFB1M

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2642

Application*: WB

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2641) (CBMAB-T1820-YJ)

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Target: TFB1M

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2641

Application*: WB

Mouse Anti-TFB1M Recombinant Antibody (CBYJT-2640) (CBMAB-T1819-YJ)

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Target: TFB1M

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2640

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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